Projekte / Projects

Prof. Dr. rer. nat. Sven Brandau

Head of the Experimental and Translational Research Division

Phone: +49-201-723-3193



Von mesenchymalen Stammzellen abgeleitete extrazelluläre Vesikel (EVs) sind ein vielversprechendes Tool für neuartige immunmodulierende Therapieansätze.  In einem Verbundprojekt kooperieren wir mit dem Institut für Transfusionsmedizin, der Klinik für Knochenmarktransplantation, dem Institut für Medizinische Mikrobiologie sowie dem Aachener Start-Up PL-Bioscience und dem Leibniz-Institut für Analytische Wissenschaften, um EVs zu optimieren und therapeutisch besser nutzbar zu machen. [...]

Human neutrophils in malignant diseases

Neutrophil granulocytes are of central importance for the protection of our body against infections. For many years neutrophils have been regarded as terminally differentiated cells, which primarily phagocytose and neutralize infectious pathogens. More recently, the field is changing in several ways: First, neutrophils are not a homogenous population of cells but rather comprise distinct subsets. [...]

Monitoring, functional analysis and clinical relevance of myeloid-derived suppressor cells (MDSC)

MDSC are a heterogeneous population of myeloid cells, which typically expand under pathological conditions. MDSC consist of myeloid cells of various differentiation and activation stages and comprise mononuclear (monocytic) and polymorphonuclear (granulocytic) subsets. The immunosuppressive activity on T cells and other types of immune cells is a hallmark of MDSC. Our lab is among the [...]

Analysis of neutrophils in the murine tumor host – in vivo veritas

In contrast to the patient-orientated work, which is by nature somewhat descriptive, in this project area we are exploring the in vivo functionality of neutrophils in the tumor host, for example by using high end microscopy, in vivo imaging, and neutrophil manipulating techniques. It is our aim to better understand the in vivo behavior of […]

Tumor microenvironment and biomarkers

Tumor tissue is not solely an accumulation of proliferating tumor cells, but rather a complex “neo-organ” additionally consisting of mesenchymal-fibroblastoid stromal cells, vasculature, various subsets of immune cells as well as structural matrix components. In this research theme we analyze several aspects of this complex multi-directional interaction. In addition, using well-defined patient cohorts, and in [...]

Cancer Immunotherapy

Starting several decades ago researchers have been trying to identify means on how to activate and direct the immune system against cancer cells. This has led to several successful therapies, which use either non-antigen-specific adjuvant activities (such as BCG immunotherapy of bladder cancer) or antigen-specific approaches (for example the well-known MAGE antigens). Antibodies, which target […]

Biomedical application of nanoparticles

Nanoparticles (NPs) are small, microscopic, 3-dimensional particles, which, according to most definitions, do not exceed 100nm in at least one dimension. In collaboration with research groups in the Faculty of Chemistry, we are exploring the interaction of NPs with immune cells as well as their potential biomedical applications. NPs can be coupled to antibodies and […]

Mesenchymal stromal cells in immunity and oncology

Mesenchymal stromal cells (MSC) are fibroblastoid progenitor cells, which have a distinct multi-lineage differentiation potential. Next to their tissue-regenerative potential MSC have potent immunomodulatory activity, which has led to their further development as cellular therapeutics, primarily in diseases with overshooting immunity. We are exploring the interaction of MSC with immune cells and tumor cells in [...]