Priv.-Doz. Dr. rer. nat. Jadwiga Jablonska

Research group leader

Tel: 0201 723 3190

jadwiga.jablonska@uk-essen.de

Projects

Type I interferons (IFNs) as immunomodulators regulating tumor associated neutrophil activation and functions

IFN-b is a member of type I IFN family that consists of several cytokines signaling through a common IFN-α/β receptor (IFNAR). It is known that a hierarchy of induction exists for this cytokine group, where IFN-b is induced first and triggers cascade of other type I IFNs via autokrine and paracrine signaling through IFNAR. IFNs [...]

Tumor exosome mediated alteration of innate and adaptive immune responses and its influence on tumorigenesis and metastatic processes

  Cooperation with Dr. S. Funk (Dept. of Otolaryngology University Hospital Essen) and Dr. B.K. Thakur (Dept. of Pediatric, University Hospital Essen)

The impact of tumor-mediated immunosuppression on the susceptibility of tumor bearing hosts for infections with nosocomial pathogen P. aeruginosa

The number of immunocompromised people is steadily increasing. One reason is an overall aging of the human population. However, also the number of medical treatments with an impact on immune function is accumulating. Such immunocompromised patients are particularly vulnerable to opportunistic infections by pathogens e.g. Pseudomonas aeruginosa. These Gram-negative bacteria are consistently identified as the […]

Neutrophil-mediated regulation of angiogenesis in growing tumors

One of the developmental hallmarks of a tumor is the induction of angiogenesis i.e. the formation of new blood vessels. Small tumors up to a size of 1-2 mm3 can be supplied with oxygen and nutrients by the surrounding tissue. For larger tumors, this is no longer sufficient. The tumor has to alter its angiogenic […]

Modification of neutrophil development and functions in patients with Morbus Osler syndrome (Hereditary hemorrhagic telangiectasia)

Hereditary Hemorrhagic Telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, is a rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation. It is characterized by recurrent epistaxis, mucocutaneous telangiectasia, and visceral arteriovenous malformations. It is an inherited genetic disorder caused by mutations in several genes (ENG, ACVRL1, SMAD4, GDF2) in the transforming growth […]

Identification of intracellular factors/signaling pathways contributing to the tumorigenic transformation of mouse and human neutrophils

Neutrophils exhibit a high functional plasticity. They might maintain pro- or anti-inflammatory properties depending on cytokine milieu e.g. type I IFN availability. Thus, alterations in neutrophil differentiation could be responsible for the changes in the host predisposition for tumor development. However, the molecular mechanisms responsible for such differentiation are not clear to date. We observe […]

Neutrophil surveillance activity in disease – translational studies

The view on neutrophils is radically changing at the moment. Neutrophils were traditionally considered to be a homogeneous population of terminally differentiated cells with defined roles in inflammation and fighting infections. However, recent advances in neutrophil research challenge this limited view and demonstrate that neutrophils are highly versatile and play different roles in various pathological […]