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AG Neutrophil Biology & Translational Oncology

Selected publications

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  1. Maier-Begandt D,* Alonso-Gonzalez N,, Klotz L,, Erpenbeck L, Jablonska J, Immler R, Hasenberg A, Müller T, Herrero-Cervera A, Aranda-Pardos I, Flora K, Zarbock A, Brandau S, Schulz C, Soehnlein O and Steiger S. Neutrophil biology and diversity in health and disease: new mechanistic insights. Nephrology Dialysis Transplantation (2023), doi: 10.1093/ndt/gfad266
  2. Pylaeva E. and Jablonska J. Sellhi neutrophils: a key to triumph in cancer therapy. Signal Transduction and Targeted Therapy (2023), doi: 10.1038/s41392-023-01671-6
  3. Wandrey, M.; Jablonska, J.; Stauber, R.H.; Gül, D. Exosomes in Cancer Progression and Therapy Resistance: Molecular Insights and Therapeutic Opportunities. Life (2023), 13, 2033. https://doi.org/10.3390/life13102033
  4. Zec K, Thiebes S, Bottek J, Siemes D, Spangenberg P, Trieu D, Kirstein N, Subramaniam N, Krauss S, Soun C, Christ R, Bonella F, Udalova I, Klein D, Jendrossek V, Pabst O, Reuter S, Loose M, Wagenlehner F, Jablonska J, Bracht T, Sitek B, Klein-Hitpass L, Gunzer M, Theegarten D, Shevchuk O, Engel D R. Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infection Front. Immunol (2023) 14:1227191. doi: 10.3389/fimmu.2023.1227191.
  5. Duerig I, Pylaeva E, Bordbari S, Spyra I, Ozel I, Domnich M, Siakaeva E, Lakomek A, Toppe F, Schleupner C, Geisthoff U, Droege F, Jablonska J Non-functional TGF-β/ALK1/ENG Signaling Pathway supports neutrophil pro-angiogenic activity in Hereditary Hemorrhagic Telangiectasia J. Leuc. Biol. (2023) * equal contribution
  6. Tengler L, Schütz J, Tiedtke M, Jablonska J, Theodoraki MN, Nitschke K, Weiß C, Seiz E, Affolter A, Jungbauer F, Lammert A, Rotter N, Ludwig N Plasma Exosomes unleash the Angiogenic Potential in Head and Neck Cancer Patients Mol Med.(Springer Nature, BMC) (2023) 29(1):69. doi: 10.1186/s10020-023-00659-w.
  7. Melo LM, Herrera-Rios D, Hinze D, Löffek S, Ozel I, Turiello R, Klein J, Leonardelli S, Westedt I-V, Al-Matary Y, Rodriguez SE, Brenzel A, Bau M, Sucker A, Hadaschik E, Wirsdörfer F, Hanenberg H, Uhlenbrock N, Rauh D, Poźniak J, Rambow F, Marine JC, Effern M, Glodde N, Schadendorf D, Jablonska J, Helfrich I, Holzl M. Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma. Journal for ImmunoTherapy of Cancer, JITC (2022) * equal contribution. doi: 10.1136/jitc-2021-004150
  8. Jablonska J, Brandau S PMN-MDSC in newborns: regulation of the regulators. J. Leuc. Biol. (2022) (editorial commentary). https://doi.org/10.1002/JLB.3CE0522-283R
  9. Antoni A.C., Pylaeva E., Jablonska J., Klein-Hitpaß L., Dudda M., B. Flohé S.B. TLR2-induced CD8+ T cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis. Frontiers in Immunol. (2022) doi: 10.3389/fimmu.2022.945409
  10. Pylaeva E, Korschunow G, Spyra I, Bordbari B, Siakaeva E, Squire A, Hasenberg A, Thangavelu K, Hussain T, Goetz M, Lang KS, Gunzer M, Hansen W, Buer J, Bankfalvi A, Lang S, Jablonska J. Neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes at the early stage of cancer. Cell Reports (2022) ;40(7):111171
  11. Hussain T., Domnich M., Bordbari S., Pylaeva E., Siakaeva E., Spyra I., Ozel I., Squire A., Sutter K., Hasenberg A., Gunzer M., Lang S., Jablonska J. IFNAR1 deficiency impairs immunostimulatory properties of neutrophils in pre-metastatic tumor-draining LNs. Front. Immunol (2022) https://doi.org/10.3389/fimmu.2022.878959
  12. Chetty VK, Ghanam J, Anchan S, Reinhardt K, Brenzel A, Gelleri M, Cremer C, Grueso Navarro E, Schneider M, von Neuhoff N, Reinhardt D, Jablonska J, Nazarenko I, Kumar Thakur B* Efficient small extracellular vesicle (EV) isolation method suitable to perform EV-DNA functional studies in the recipient cells. Cancers (2022) 14(9):2068, DOI: 10.3390/ cancers14092068
  13. Wrobeln A, Leu T, Jablonska J, Geisthoff U, Lang S, Fandrey J and Droege F. Altered Hypoxia Inducible Factor Regulation in Hereditary Hemorrhagic Telangiectasia. Scientific Reports 12, 5877 (2022). https://doi.org/10.1038/s41598-022-09759-9
  14. Jablonska J, Rist M, Spyra I, Tengler L, Domnich M, Kansy B, Giebel B, Thakur BK, Rotter, Lang S, Ludwig S* Evaluation of immunoregulatory biomarkers on plasma small extracellular vesicles for disease progression and early therapeutic response in Head and Neck Cancer. Cells (2022) 11(5):902; DOI: 10.3390/cells11050902
  15. Ozel I, Duerig I, Domnich M, Lang S, Pylaeva E and Jablonska J. The Good, the Bad and the Ugly: Neutrophils, angiogenesis and cancer. Cancers (2022) accepted
  16. Siakaeva E, Jablonska J. Pre-metastatic Niche Formation by Neutrophils in Different Organs. Adv Exp Med Biol. (2021) 1329:93-108. doi: 10.1007/978-3-030-73119-9_5
  17. Bordbari S, Mörchen B, Pylaeva E, Siakaeva E, Spyra I, Droege F, Kanaan O, Schadendorf D, Lang S, Helfrich I, Jablonska J. SIRT1-mediated deacetylation of FOXO3a transcription factor supports pro-angiogenic activity of interferon-deficient tumor-associated neutrophils.. Int. J Cancer (2021) Nov 9. doi: 10.1002/ijc.33871. Epub ahead of print.
  18. Pylaeva E, Ozel I, Squire A, Spyra I, Wallner C, Korek M, Korschunow G, Siakaeva E, Goetz M, Bankfalvi A, Lang S, Kansy B, Jablonska J. B-helper neutrophils in tumor-draining lymph nodes are associated with improved prognosis in patients with head and neck cancer. Cancers (2021) 13(12), 3092
  19. Mülling K, Fischer AJ, Siakaeva E, Richter M, Borbardi S, Spyra I, Köster C, Felderhoff-Müser U, Bendix I; Gunzer M, Jablonska J, Herz J. Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia. Brain Behavior and Immunity (2021) 14;S0889-1591(20)32455-7
  20. Domnich M, Riedesel J, Pylaeva E, Kürten C.H.L., Buer J, Lang S and Jablonska J. Oral neutrophils – underestimated players in oral cancer. Frontiers in Immunology (2020); https://doi.org/10.3389/fimmu.2020.565683
  21. Lang S, Brandau S, Marchesi J, Jablonska J, Thurnher D, Mattheis S, Buer J, Hussain T. Das Mikrobiom bei Kopf-Hals-Tumoren – Erste Erkenntnisse und Ausblick. HNO (2020) 68(12), 905-910
  22. Jablonska J, Rist M, Lang S and Brandau S. Neutrophils in the tumor microenvironment – friend or foe? HNO (2020) 68(12), 891-898
  23. Ludwig S, Rotter N, Theodoraki M-N, Jablonska J, Lammert A, Lang S. Exosomen als Immunregulatoren in Kopf-Hals-Karzinomen HNO (2020) 68, 719–725
  24. Droege F, Pylaeva E, Siakaeva E, Bordbari S, Spyra I, Thangavelu K, Lueb C, Domnich M, Lang S, Geisthoff U, Jablonska J. Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia. J. Clin. Med. (2020) , 9(3), 767
  25. Siakaeva E, Pylaeva E, Spyra I, Bordbari S, Höing B, Kürten C, Lang S, Jablonska J. Neutrophil maturation and survival is controlled by IFN-dependent regulation of NAMPT signaling. Int. J Mol. Sciences. (2019) 20(22). pii: E5584.
  26. Pylaeva E, Bordbari S, Spyra I, Decker A, Häussler S, Vybornov V, Lang S and Jablonska J. Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis. Frontiers in Immunology (2019); https://doi.org/10.3389/fimmu.2019.02190
  27. Decker AS, Pylaeva E, Brenzel A, SpyraI, Droege F, HussainT, Lang S and Jablonska J. Prognostic Role of Blood NETosis in the Progression of Head and Neck Cancer. Cells (2019) 8(9), 946; https://doi.org/10.3390/cells8090946
  28. Pylaeva E, Spyra I, Bordbari S, Lang S and Jablonska J. Transfer of Manipulated Tumor-Associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo. (2019) J. Vis. Exp. (2019); (149), e59807, doi:10.3791/59807.
  29. Jablonska J, Pietrowska M, Ludwig S, Lang S, Kumar Thakur B. Challenges in the isolation and proteomic analysis of cancer exosomes – implications for translational research. Proteomes. (2019); 7(2). pii: E22.
  30. Pylaeva E, Dehghan Harati M, Spyra I, Bordbari S, Strachan S, Kumar Thakur B, Höing B, Franklin C, Skokowa J, Welte K, Schadendorf D, Bankfalvi A, Brandau S, Lang S and Jablonska J NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils. Int. J Cancer (2019); 144(1):136-149
  31. Umansky V, Adema G, Baran J, Brandau S, van Ginderachter JA, Hu Xiaoying, Jablonska J, Mojsilovic S, Papadaki H, Pico de Coana Y, Santegoets K, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender Z Interactions among myeloid regulatory cells in cancer. Cancer Immunol Immunother (2019); 68(4):645-660. doi: 10.1007/s00262-018-2200-6.
  32. Jablonska J, Lang S, Sionov RV and Granot Z: The regulation of pre-metastatic niche formation by neutrophils. Oncotarget. (2017); 8(67):112132-112144. https://doi.org/10.18632/oncotarget.22792
  33. Jablonska J, Granot Z: Neutrophil, Quo Vadis J. Leuc. Biol. (2017); 102(3):685-688
  34. Pylaeva E, Lang S and Jablonska J: The essential role of type I interferons in differentiation and activation of tumor associated neutrophils. Frontiers in Immunology. (2016); 7:629. doi: 10.3389/fimmu.2016.00629 eCollection 2016
  35. Andzinski L, Spanier J, Kasnitz N, Kröger A, Jin L, Brinkmann MM, Kalinke U, Weiss S, Jablonska J. and Lienenklaus S: Growing tumors induce a local STING dependent Type I IFN response in dendritic cells. Int. J. Cancer (2016); 139(6):1350-7 *equal contribution
  36. Nocera D.A., Nuñez N.G., Lienenklaus S, Jablonska J, Weiss S, Roselli E, Araya P, Gatti G, Morón G and Maccioni M: In vivo visualizing the IFN-β response required for tumor growth control in therapeutic model of Poly A:U administration. J. Immunol. (2016); 196(6):2860-9. doi: 10.4049/jimmunol.1501044.
  37. Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Köckritz-Blickwede M, Schilling B, Brandau S, Weiss S and Jablonska J: Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int. J. Cancer (2016); 138, (8) 1982-1993 DOI: 10.1002/ijc.29945
  38. Granot Z and Jablonska J, Distinct Functions of Neutrophil in Cancer and Its Regulation. Mediators of Inflammation. (2015) 2015:701067. doi: 10.1155/2015/701067
  39. Wu CF, Andzinski L, Kasnitz N, Kröger A, Klawonn F, Lienenklaus S, Weiss S and Jablonska J: The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung. Int. J. Cancer. (2015); 137(4):837-47. DOI: 10.1002/ijc.29444
  40. Andzinski L, Wu CF, Lienenklaus S, Kröger A, Weiss S and Jablonska J: Delayed apoptosis of tumor associated neutrophils in absence of endogenous IFN-β Int. J. Cancer. (2015); 136 (3): 572–583
  41. Jablonska J: To NET or not to NET. Am. J. Immunol, (2014) DOI 10.3844/ajisp.2014.166.168
  42. Jablonska J, Wu CF, Andzinski L, Leschner S and Weiss S: CXCR2-mediated tumor associated neutrophil recruitment is regulated by IFN-β Int. J. Cancer (2014); 134(6):1346-58
  43. Viegas N, Andzinski L, Wu C.-F, Komoll R, Gekara N, Dittmar K E, Weiss S and Jablonska J: IFN- production by CD27+ NK cells exacerbates Listeria monocytogenes infection in mice by inhibiting granulocyte mobilization Eur. J. Immunol. (2013); 43(10):2626-37
  44. Solodova E, Jablonska J, Weiss S and Linienklaus S Production of IFN during Listeria monocytogenes Infection is Restricted to Macrophages Plos ONE (2011); 6:e18543
  45. Łyszkiewicz M, Ziętara N, Rohde M, Gekara N, Jablonska J, Dittmar K E, and Weiss S: SIGN-R1+MHC II+ cells of the splenic marginal zone – a novel type of resident dendritic cells J. Leuc. Biol. (2011); 89:607-15.
  46. Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, Ruiz G, Zietara N, Jablonska J, Weiss S, Hoffmann A, Jorgensen C, Apparailly F and Gross G: In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells Blood (2010); 116: 3505 – 3516.
  47. Jablonska J, Leschner S, Westphal K, Lienenklaus S and Weiss S: Neutrophils responsive to endogenous IFN beta regulate tumor angiogenesis and growth in a mouse tumor model J. Clin. Invest. (2010); 120:1151-64
  48. Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, Lienenklaus S, Falk W, Gekara N, Loessner H and Weiss S Tumor invasion of Salmonella enterica serovar Typhimurium by vascular disruption Plos ONE. (2009); 4:e6692
  49. Lienenklaus S, Cornitescu M, Zietara N, Lyszkiewicz M, Gekara N, Jablonska J, Edenhofer F, Rajewsky K, Bruder D, Hafner M, Staeheli P. and Weiss S. Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo J. Immunol. (2009); 183:3229-36
  50. Westphal K, Leschner S, Jablonska J, Loessner H, Weiss S. Containment of tumor colonizing bacteria by host neutrophils Cancer Res. (2008); 68: 2952-60
  51. Ma B, Jablonska J, Lindenmaier W, Dittmar K.E. Immunohistochemical study of microanatomy of mouse lymph node using vibratome sections Acta Histochem. (2007); 109:15-28
  52. Ma B, He F, Jablonska J, Winkelbach S, Zeng A-P, Lindenmaier W, Dittmar K.E. Six-colour segmentation analysis of multi-colour images in the infection studies using Listeria monocytogenes Microsc. Res. Tech. (2006); 19; 70: 171-178
  53. Becker C, Lienenklaus S, Jablonska J, Bauer H and Weiss S. Retrovirally transduced IFN is posttranscriptionally regulated adding limited therapeutic potency to tumor-specific CD8+ T cells J. Mol. Med. (2007); 85:63-73
  54. Forster N, Gallinat S, Jablonska J, Weiss S, Elsässer H-P and Lutz W. p300 protein acetyltransferase-activity suppresses SLElike autoimmune disease in mice J. Immunol. (2007); 178:6941-8
  55. Jablonska J, Dittmar KE, Kleinke T, Buer J and Weiss S Essential role of CCL2 in clustering of splenic ERTR-9+ macrophages during infection with Listeria monocytogenes. Infect. Immun. (2007); 75:462-70